PDBe 1dic

X-ray diffraction
1.8Å resolution

STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D

Released:
Source organism: Homo sapiens
Primary publication:
Structure of 3,4-dichloroisocoumarin-inhibited factor D.
Acta Crystallogr. D Biol. Crystallogr. 54 711-7 (1998)
PMID: 9757085

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor D Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 24.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00746 (Residues: 26-253; Coverage: 98%)
Gene names: CFD, DF, PFD
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 56.3Å b: 51.57Å c: 39.84Å
α: 90° β: 106.05° γ: 90°
R-values:
R R work R free
0.182 0.182 0.251