Function and Biology

CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI

Source organism: Penicillium roqueforti
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 4.2.3.9: Aristolochene synthase

Reaction catalysed:
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.
Comments:
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23).
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC 2.5.1.40 and EC 4.1.99.7.
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)
Alternative Name(s):
  • Trans,trans-farnesyl diphosphate aristolochene-lyase
  • Sesquiterpene cyclase
  • Trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotation
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. Aristolochene synthase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. Aristolochene synthase
1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in Aristolochene synthase in PDB 1di1.
SCOP SCOP annotation
48586
Class: All alpha proteins
Fold: Terpenoid synthases
Superfamily: Terpenoid synthases
Occurring in:
  1. Aristolochene synthase
1 copy of SCOP domain 48586 (Aristolochene/pentalenene synthase) in Aristolochene synthase in PDB 1di1.