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CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE

Source organism: Homo sapiens
Biochemical function: sequence-specific mRNA binding
Biological process: regulation of removal of superoxide radicals
Cellular component: cytosol

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EC 1.5.1.3: Dihydrofolate reductase

Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
  • 7,8-dihydrofolate reductase
  • DHFR
  • Dihydrofolate reductase:thymidylate synthase
  • Dihydrofolic acid reductase
  • Dihydrofolic reductase
  • Folic acid reductase
  • Folic reductase
  • NADPH-dihydrofolate reductase
  • Pteridine reductase:dihydrofolate reductase
  • Tetrahydrofolate dehydrogenase
  • Thymidylate synthetase-dihydrofolate reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00186
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 1dhf contains 2 copies of Pfam domain PF00186 (Dihydrofolate reductase) in Dihydrofolate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001796
Domain description: Dihydrofolate reductase domain
Occurring in:
  1. Dihydrofolate reductase
IPR024072
Domain description: Dihydrofolate reductase-like domain superfamily
Occurring in:
  1. Dihydrofolate reductase
IPR017925
Domain description: Dihydrofolate reductase conserved site
Occurring in:
  1. Dihydrofolate reductase
IPR012259
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase

Structure domain

CATH CATH domain
3.40.430.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Dihydrofolate Reductase, subunit A
Homology: Dihydrofolate Reductase, subunit A
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 1dhf contains 2 copies of CATH domain 3.40.430.10 (Dihydrofolate Reductase, subunit A) in Dihydrofolate reductase. Showing 1 copy in chain A.
SCOP SCOP annotation
53598
Class: Alpha and beta proteins (a/b)
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 1dhf contains 2 copies of SCOP domain 53598 (Dihydrofolate reductases) in Dihydrofolate reductase. Showing 1 copy in chain A.

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