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INTERACTIONS BETWEEN HIV-1 GP41 CORE AND DETERGENTS AND THEIR IMPLICATIONS FOR MEMBRANE FUSION

X-ray diffraction
2.7Å resolution
PDB entry 1df5 coloured by chain, front view.
PDB entry 1df5 coloured by chain, side view.
PDB entry 1df5 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transmembrane protein gp41
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Multimeric state: homo trimer
Accessible surface area: 10768.46 Å2
Buried surface area: 6618.07 Å2
Dissociation area: 3,309.04 Å2
Dissociation energy (ΔGdiss): 39.9 kcal/mol
Dissociation entropy (TΔSdiss): 22.62 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-137976

Macromolecules

Transmembrane protein gp41
Chain: A
Length: 68 amino acids
Theoretical weight: 7.88 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-655; Coverage: 8%)
Gene name: env
Pfam: Retroviral envelope protein
CATH: Helix Hairpins
SCOP: Virus ectodomain
Transmembrane protein gp41 in PDB entry 1df5, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 1df5, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 1df5, assembly 1, top view.
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