› 1dbj

X-ray diffraction
2.7Å resolution

MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY

Released:
DOI: 10.2210/pdb1dbj/pdb
PDB entry 1dbj coloured by chain, front view.
PDB entry 1dbj coloured by chain, side view.
PDB entry 1dbj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular basis of crossreactivity and the limits of antibody-antigen complementarity.
Arevalo JH, Taussig MJ, Wilson IA
Nature 365 859-63 (1993)
PMID: 8413674

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208670 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGG1-KAPPA DB3 FAB (LIGHT CHAIN) Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.88 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
Ig gamma-1 chain C region secreted form Chain: H
Molecule details ›
Chain: H
Length: 219 amino acids
Theoretical weight: 23.75 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P01868 (Residues: 1-100; Coverage: 31%)
Gene names: Igh-4, Ighg1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand AE2 1 x AE2
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6422
Unit cell:
a: 134.76Å b: 134.76Å c: 124.21Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 not available
Expression system: Not provided

Quick links

Citations

17 review citations

Macromolecular modeling with rosetta.
Das et al. (2008)
16 more

13 mentions without citation

Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding.
Young et al. (2007)
12 more