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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB

X-ray diffraction
2.45Å resolution
PDB entry 1d5x coloured by chain, front view.
PDB entry 1d5x coloured by chain, side view.
PDB entry 1d5x coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 27864.31 Å2
Buried surface area: 8164.94 Å2
Dissociation area: 724.69 Å2
Dissociation energy (ΔGdiss): -2.12 kcal/mol
Dissociation entropy (TΔSdiss): 12.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-216677

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1d5x, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1d5x, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1d5x, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 192 amino acids
Theoretical weight: 22.52 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1d5x, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1d5x, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1d5x, assembly 1, top view.
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Enterotoxin type B
Chain: C
Length: 239 amino acids
Theoretical weight: 28.41 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P01552 (Residues: 28-266; Coverage: 100%)
Gene name: entB
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type B in PDB entry 1d5x, assembly 1, front view.
Enterotoxin type B in PDB entry 1d5x, assembly 1, side view.
Enterotoxin type B in PDB entry 1d5x, assembly 1, top view.
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DIPEPTIDE MIMETIC INHIBITOR
Chain: D
Length: 6 amino acids
Theoretical weight: 741 Da
DIPEPTIDE MIMETIC INHIBITOR in PDB entry 1d5x, assembly 1, front view.
DIPEPTIDE MIMETIC INHIBITOR in PDB entry 1d5x, assembly 1, side view.
DIPEPTIDE MIMETIC INHIBITOR in PDB entry 1d5x, assembly 1, top view.
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