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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG

X-ray diffraction
1.6Å resolution
PDB entry 1d3g coloured by chain, front view.
PDB entry 1d3g coloured by chain, side view.
PDB entry 1d3g coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
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Multimeric state: monomeric
Accessible surface area: 14697.0 Å2
Buried surface area: 3046.85 Å2
Dissociation area: 342.37 Å2
Dissociation energy (ΔGdiss): -10.65 kcal/mol
Dissociation entropy (TΔSdiss): 3.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169672

Macromolecules

Dihydroorotate dehydrogenase (quinone), mitochondrial
Chain: A
Length: 367 amino acids
Theoretical weight: 39.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 29-395; Coverage: 93%)
Gene name: DHODH
Pfam: Dihydroorotate dehydrogenase
InterPro:
CATH: Aldolase class I
SCOP: FMN-linked oxidoreductases
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 1d3g, assembly 1, front view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 1d3g, assembly 1, side view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 1d3g, assembly 1, top view.
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