PDBe 1cwe

X-ray diffraction
2.3Å resolution

HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Lck Chains: A, C
Molecule details ›
Chains: A, C
Length: 98 amino acids
Theoretical weight: 11.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 127-222; Coverage: 19%)
Gene name: LCK
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein
PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO Chains: B, D
Molecule details ›
Chains: B, D
Length: 7 amino acids
Theoretical weight: 882 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 35.17Å b: 41.84Å c: 45.52Å
α: 68.71° β: 82.94° γ: 87.36°
R-values:
R R work R free
0.192 0.192 not available
Expression systems:
  • Escherichia coli
  • Not provided