PDBe 1cvu

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

Released:

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PROTEIN (9-MER) Chain: F
Molecule details ›
Chain: F
Length: 9 amino acids
Theoretical weight: 907 Da
Source organism: Synthetic construct
Expression system: Not provided
Prostaglandin G/H synthase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 552 amino acids
Theoretical weight: 63.42 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 18-569; Coverage: 94%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: I222
Unit cell:
a: 181.036Å b: 133.96Å c: 124.834Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.235
Expression systems:
  • Not provided
  • Spodoptera frugiperda