PDBe 1csk

X-ray diffraction
2.5Å resolution

THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase CSK Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 71 amino acids
Theoretical weight: 7.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P41240 (Residues: 1-71; Coverage: 16%)
Gene name: CSK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 64.9Å b: 74.69Å c: 125.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.278
Expression system: Not provided