PDBe 1cs8

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF PROCATHEPSIN L

Released:

Function and Biology Details

Reaction catalysed:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin L1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.92 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07711 (Residues: 18-333; Coverage: 100%)
Gene names: CTSL, CTSL1
Sequence domains:
Structure domains: Cysteine proteinases

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P3221
Unit cell:
a: 104.29Å b: 104.29Å c: 85.99Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.207 0.228
Expression system: Komagataella pastoris