PDBe 1cqq

X-ray diffraction
1.85Å resolution

Function and Biology Details

Reactions catalysed:
NTP + H(2)O = NDP + phosphate. 
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protease 3C Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 19.98 KDa
Source organism: Human rhinovirus A2
UniProt:
  • Canonical: P04936 (Residues: 1508-1687; Coverage: 8%)
Sequence domains: 3C cysteine protease (picornain 3C)
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 34.3Å b: 65.7Å c: 77.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 not available not available