PDBe 1cqe

X-ray diffraction
3.1Å resolution

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN

Released:
Source organism: Ovis aries

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 580 amino acids
Theoretical weight: 66.6 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 21-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-21
Spacegroup: I222
Unit cell:
a: 99.4Å b: 210.3Å c: 233.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.226