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THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT

Source organism: Escherichia coli K-12
Biochemical function: DNA-directed 5'-3' RNA polymerase activity
Biological process: DNA-templated transcription
Cellular component: not assigned

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03118
Domain description: Bacterial RNA polymerase, alpha chain C terminal domain
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 1coo contains 1 copy of Pfam domain PF03118 (Bacterial RNA polymerase, alpha chain C terminal domain) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR011260
Domain description: RNA polymerase, alpha subunit, C-terminal
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha

Structure domain

CATH CATH domain
1.10.150.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: 5' to 3' exonuclease, C-terminal subdomain
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 1coo contains 1 copy of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A.
SCOP SCOP annotation
47790
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: C-terminal domain of RNA polymerase alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 1coo contains 1 copy of SCOP domain 47790 (C-terminal domain of RNA polymerase alpha subunit) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A.

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