PDBe 1cm0

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. 
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 19.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92831 (Residues: 491-658; Coverage: 20%)
Gene names: KAT2B, PCAF
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P64
Unit cell:
a: 97Å b: 97Å c: 77.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.223 0.268
Expression system: Escherichia coli BL21(DE3)