PDBe 1cjy

X-ray diffraction
2.5Å resolution

HUMAN CYTOSOLIC PHOSPHOLIPASE A2

Released:

Function and Biology Details

Reactions catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. 
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. 

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic phospholipase A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 749 amino acids
Theoretical weight: 85.31 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P47712 (Residues: 1-749; Coverage: 100%)
Gene names: CPLA2, PLA2G4, PLA2G4A
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 153.59Å b: 95.49Å c: 139.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.298
Expression system: Cricetulus griseus