EC 3.4.22.15: Cathepsin L
Reaction catalysed:
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Systematic name:
-
Alternative Name(s):
- Aldrichina grahami cysteine proteinase
GO terms
Biochemical function:
Biological process:
- positive regulation of apoptotic signaling pathway
- cellular response to thyroid hormone stimulus
- macrophage apoptotic process
- elastin catabolic process
- proteolysis involved in protein catabolic process
- antigen processing and presentation of peptide antigen
- symbiont entry into host cell
- CD4-positive, alpha-beta T cell lineage commitment
- fusion of virus membrane with host endosome membrane
- enkephalin processing
- zymogen activation
- collagen catabolic process
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- antigen processing and presentation
- receptor-mediated endocytosis of virus by host cell
- fusion of virus membrane with host plasma membrane
- protein autoprocessing
- immune response
- proteolysis
- adaptive immune response
Cellular component:
- endocytic vesicle lumen
- extracellular exosome
- collagen-containing extracellular matrix
- intracellular membrane-bounded organelle
- lysosomal lumen
- chromaffin granule
- endolysosome lumen
- cytoplasmic vesicle
- apical plasma membrane
- plasma membrane
- Golgi apparatus
- multivesicular body
- lysosome
- nucleus
- extracellular space
- extracellular region
Protein families (Pfam)
InterPro annotations
CATH domain
SCOP annotation