Structure analysis

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 9200 Å2
Buried surface area: 3200 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 7 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -14 kcal/mol
Symmetry number: 2
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 9200 Å2
Buried surface area: 3200 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 2
Assembly 3
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Multimeric state: homo dimer
Accessible surface area: 9200 Å2
Buried surface area: 3200 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 2
Assembly 4
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Multimeric state: homo dimer
Accessible surface area: 9200 Å2
Buried surface area: 3300 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 7 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 2
Assembly 5
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Multimeric state: homo dimer
Accessible surface area: 9200 Å2
Buried surface area: 3200 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 2
Assembly 6
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Multimeric state: homo dimer
Accessible surface area: 9300 Å2
Buried surface area: 3200 Å2
Dissociation area: 800 Å2
Dissociation energy (ΔGdiss): 7 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 96 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 57-152; Coverage: 44%)
Gene names: ASH, GRB2
Pfam: SH2 domain
InterPro:
CATH: SHC Adaptor Protein
SCOP: SH2 domain

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