PDBe 1ci6

X-ray diffraction
2.6Å resolution

TRANSCRIPTION FACTOR ATF4-C/EBP BETA BZIP HETERODIMER

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclic AMP-dependent transcription factor ATF-4 Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18848 (Residues: 280-341; Coverage: 18%)
Gene names: ATF4, CREB2, TXREB
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
CCAAT/enhancer-binding protein beta Chain: B
Molecule details ›
Chain: B
Length: 63 amino acids
Theoretical weight: 7.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28033 (Residues: 224-285; Coverage: 21%)
Gene name: Cebpb
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P2221
Unit cell:
a: 72.628Å b: 81.152Å c: 35.317Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.273
Expression system: Escherichia coli BL21(DE3)