Function and Biology

STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: interleukin-12-mediated signaling pathway
Cellular component: extracellular exosome

EC 2.4.2.28: S-methyl-5'-thioadenosine phosphorylase

Reaction catalysed:
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate.
Comments:
  • Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.
Systematic name:
S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Alternative Name(s):
  • 5'-deoxy-5'-methylthioadenosine phosphorylase
  • 5'-methylthioadenosine phosphorylase
  • 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase
  • MTA phosphorylase
  • MeSAdo phosphorylase
  • MeSAdo/Ado phosphorylase
  • Methylthioadenosine nucleoside phosphorylase
  • Methylthioadenosine phosphorylase
  • MTAPase
  • S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase

Sequence family

Pfam Protein family (Pfam)
PF01048
Domain description: Phosphorylase superfamily
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
1 copy of Pfam domain PF01048 (Phosphorylase superfamily) in S-methyl-5'-thioadenosine phosphorylase in PDB 1cg6.

InterPro InterPro annotations
IPR010044
Domain description: Methylthioadenosine phosphorylase (MTAP)
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
IPR035994
Domain description: Nucleoside phosphorylase superfamily
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
IPR018099
Domain description: Purine phosphorylase, family 2, conserved site
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
IPR000845
Domain description: Nucleoside phosphorylase domain
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase

Structure domain

CATH CATH domain
3.40.50.1580
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
1 copy of CATH domain 3.40.50.1580 (Rossmann fold) in S-methyl-5'-thioadenosine phosphorylase in PDB 1cg6.
SCOP SCOP annotation
53168
Class: Alpha and beta proteins (a/b)
Fold: Phosphorylase/hydrolase-like
Superfamily: Purine and uridine phosphorylases
Occurring in:
  1. S-methyl-5'-thioadenosine phosphorylase
1 copy of SCOP domain 53168 (Purine and uridine phosphorylases) in S-methyl-5'-thioadenosine phosphorylase in PDB 1cg6.