Structure analysis

STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION

X-ray diffraction
1.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 30000 Å2
Buried surface area: 9400 Å2
Dissociation area: 3,500 Å2
Dissociation energy (ΔGdiss): 38 kcal/mol
Dissociation entropy (TΔSdiss): 27 kcal/mol
Interface energy (ΔGint): -122 kcal/mol
Symmetry number: 3

Macromolecules

Chain: A
Length: 283 amino acids
Theoretical weight: 31.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13126 (Residues: 1-283; Coverage: 100%)
Gene names: MSAP, MTAP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Rossmann fold
SCOP: Purine and uridine phosphorylases

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