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SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP

Solution NMR
PDB entry 1cee coloured by chain, ensemble of 20 models, front view.
PDB entry 1cee coloured by chain, ensemble of 20 models, side view.
PDB entry 1cee coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Actin nucleation-promoting factor WAS and Cell division control protein 42 homolog
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Multimeric state: hetero dimer
Accessible surface area: 13198.14 Å2
Buried surface area: 3707.29 Å2
Dissociation area: 1,413.59 Å2
Dissociation energy (ΔGdiss): 15.3 kcal/mol
Dissociation entropy (TΔSdiss): 11.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154863

Macromolecules

Cell division control protein 42 homolog
Chain: A
Length: 179 amino acids
Theoretical weight: 19.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60953 (Residues: 1-179; Coverage: 94%)
Gene name: CDC42
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Cell division control protein 42 homolog in PDB entry 1cee, assembly 1, front view.
Cell division control protein 42 homolog in PDB entry 1cee, assembly 1, side view.
Cell division control protein 42 homolog in PDB entry 1cee, assembly 1, top view.
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Actin nucleation-promoting factor WAS
Chain: B
Length: 59 amino acids
Theoretical weight: 6.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42768 (Residues: 230-288; Coverage: 12%)
Gene names: IMD2, WAS
Pfam: P21-Rho-binding domain
InterPro:
CATH: CRIB domain
Actin nucleation-promoting factor WAS in PDB entry 1cee, assembly 1, front view.
Actin nucleation-promoting factor WAS in PDB entry 1cee, assembly 1, side view.
Actin nucleation-promoting factor WAS in PDB entry 1cee, assembly 1, top view.
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