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CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C

X-ray diffraction
2Å resolution
PDB entry 1cdk coloured by chain, front view.
PDB entry 1cdk coloured by chain, side view.
PDB entry 1cdk coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase inhibitor alpha and cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 15935.12 Å2
Buried surface area: 3698.5 Å2
Dissociation area: 1,115.04 Å2
Dissociation energy (ΔGdiss): 7.42 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153239
Assembly 2
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Assembly Name: cAMP-dependent protein kinase inhibitor alpha and cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 15897.21 Å2
Buried surface area: 3711.84 Å2
Dissociation area: 1,115.45 Å2
Dissociation energy (ΔGdiss): 6.5 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153239

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chains: A, B
Length: 350 amino acids
Theoretical weight: 40.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P36887 (Residues: 2-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1cdk, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1cdk, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1cdk, assembly 1, top view.
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cAMP-dependent protein kinase inhibitor alpha
Chains: I, J
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61926 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1cdk, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1cdk, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1cdk, assembly 1, top view.
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