Structure analysis

STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A PEPTIDE FROM TNF-R2

X-ray diffraction
2.3Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero pentamer (preferred)
homo trimer
hetero octamer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 28200 Å2
Buried surface area: 6500 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -47 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: homo trimer
Accessible surface area: 26800 Å2
Buried surface area: 4400 Å2
Dissociation area: 2,200 Å2
Dissociation energy (ΔGdiss): 18 kcal/mol
Dissociation entropy (TΔSdiss): 26 kcal/mol
Interface energy (ΔGint): -36 kcal/mol
Symmetry number: 3
Assembly 3
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Multimeric state: hetero octamer
Accessible surface area: 28200 Å2
Buried surface area: 6500 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -47 kcal/mol
Symmetry number: 1

Macromolecules

Chains: G, H
Length: 10 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20333 (Residues: 420-428; Coverage: 2%)
Gene names: TNFBR, TNFR2, TNFRSF1B

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Chains: A, B, C, D, E, F
Length: 192 amino acids
Theoretical weight: 21.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q12933 (Residues: 310-501; Coverage: 38%)
Gene names: TRAF2, TRAP3
InterPro:
CATH: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
SCOP:

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