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BOVINE CHYMOTRYPSIN COMPLEXED TO APPI

X-ray diffraction
2.1Å resolution
PDB entry 1ca0 coloured by chain, front view.
PDB entry 1ca0 coloured by chain, side view.
PDB entry 1ca0 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Amyloid-beta protein 40/42 complex and Chymotrypsin A chain C
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Multimeric state: hetero tetramer
Accessible surface area: 12039.48 Å2
Buried surface area: 8627.89 Å2
Dissociation area: 751.17 Å2
Dissociation energy (ΔGdiss): 6.65 kcal/mol
Dissociation entropy (TΔSdiss): 10.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133407
Assembly 2 (preferred)
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Assembly Name: Amyloid-beta protein 40/42 complex and Chymotrypsin A chain C
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Multimeric state: hetero tetramer
Accessible surface area: 11973.77 Å2
Buried surface area: 8680.98 Å2
Dissociation area: 752.79 Å2
Dissociation energy (ΔGdiss): 7.41 kcal/mol
Dissociation entropy (TΔSdiss): 10.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133407

Macromolecules

Chymotrypsin A chain A
Chains: A, F
Length: 13 amino acids
Theoretical weight: 1.25 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00766 (Residues: 1-13; Coverage: 5%)
SCOP: Eukaryotic proteases
Chymotrypsin A chain A in PDB entry 1ca0, assembly 2, front view.
Chymotrypsin A chain A in PDB entry 1ca0, assembly 2, side view.
Chymotrypsin A chain A in PDB entry 1ca0, assembly 2, top view.
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Chymotrypsin A chain B
Chains: B, G
Length: 131 amino acids
Theoretical weight: 13.93 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00766 (Residues: 16-146; Coverage: 54%)
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Chymotrypsin A chain B in PDB entry 1ca0, assembly 2, front view.
Chymotrypsin A chain B in PDB entry 1ca0, assembly 2, side view.
Chymotrypsin A chain B in PDB entry 1ca0, assembly 2, top view.
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Chymotrypsin A chain C
Chains: C, H
Length: 97 amino acids
Theoretical weight: 10.07 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00766 (Residues: 149-245; Coverage: 40%)
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Chymotrypsin A chain C in PDB entry 1ca0, assembly 2, front view.
Chymotrypsin A chain C in PDB entry 1ca0, assembly 2, side view.
Chymotrypsin A chain C in PDB entry 1ca0, assembly 2, top view.
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Soluble APP-beta
Chains: D, I
Length: 54 amino acids
Theoretical weight: 6.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 289-342; Coverage: 7%)
Gene names: A4, AD1, APP
Pfam: Kunitz/Bovine pancreatic trypsin inhibitor domain
InterPro:
CATH: Pancreatic trypsin inhibitor Kunitz domain
SCOP: Small Kunitz-type inhibitors & BPTI-like toxins
Soluble APP-beta in PDB entry 1ca0, assembly 2, front view.
Soluble APP-beta in PDB entry 1ca0, assembly 2, side view.
Soluble APP-beta in PDB entry 1ca0, assembly 2, top view.
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