PDBe 1c25

X-ray diffraction
2.3Å resolution

HUMAN CDC25A CATALYTIC DOMAIN

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
M-phase inducer phosphatase 1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 19.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30304 (Residues: 337-496; Coverage: 31%)
Gene name: CDC25A
Sequence domains: Rhodanese-like domain
Structure domains: Oxidized Rhodanese, domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P41
Unit cell:
a: 43.507Å b: 43.507Å c: 117.096Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.296
Expression system: Escherichia coli BL21(DE3)