PDBe 1c0e

X-ray diffraction
2.2Å resolution

Active Site S19A Mutant of Bovine Heart Phosphotyrosyl Phosphatase


Function and Biology Details

Reactions catalysed:
A phosphate monoester + H(2)O = an alcohol + phosphate. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Low molecular weight phosphotyrosine protein phosphatase Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.93 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
  • Canonical: P11064 (Residues: 2-158; Coverage: 99%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 43.32Å b: 55.47Å c: 131.45Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.191 0.244
Expression system: Escherichia coli