Function and Biology

PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE

Source organism: Bos taurus
Biochemical function: identical protein binding
Biological process: spermatogenesis
Cellular component: extracellular exosome

EC 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

Reaction catalysed:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl- sn-glycero-3-phosphocholine + acetate.
Systematic name:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
Alternative Name(s):
  • 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase
  • Alkylacetyl-GPC:acetylhydrolase
  • LDL-associated phospholipase A(2)
  • PAF acetylhydrolase
  • LDL-PLA(2)
  • PAF 2-acylhydrolase
  • Platelet-activating factor acetylhydrolase
  • 2-acetyl-1-alkylglycerophosphocholine esterase

Sequence family

CATH Protein family (Pfam)
PF13472
Domain description: GDSL-like Lipase/Acylhydrolase family
Occurring in:
  1. Platelet-activating factor acetylhydrolase IB subunit gamma
1 copy of Pfam domain PF13472 (GDSL-like Lipase/Acylhydrolase family) in Platelet-activating factor acetylhydrolase IB subunit gamma in PDB 1bwp.

CATH InterPro annotation
IPR013830
Domain description: SGNH hydrolase-type esterase domain
Occurring in:
  1. Platelet-activating factor acetylhydrolase IB subunit gamma

Structure domain

CATH CATH domain
3.40.50.1110
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Platelet-activating factor acetylhydrolase IB subunit gamma
1 copy of CATH domain 3.40.50.1110 (Rossmann fold) in Platelet-activating factor acetylhydrolase IB subunit gamma in PDB 1bwp.
SCOP SCOP annotation
52273
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: SGNH hydrolase
Occurring in:
  1. Platelet-activating factor acetylhydrolase IB subunit gamma
1 copy of SCOP domain 52273 (Acetylhydrolase) in Platelet-activating factor acetylhydrolase IB subunit gamma in PDB 1bwp.