EC 3.4.24.80: Membrane-type matrix metalloproteinase-1
Reaction catalysed:
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
Systematic name:
-
Alternative Name(s):
- Matrix metalloproteinase 14
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1buv contains 1 copy of Pfam domain PF00965 (Tissue inhibitor of metalloproteinase) in Metalloproteinase inhibitor 2. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_2_T_Pfam_PF00965_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of Pfam domain <span class='highlight'>PF00965 (Tissue inhibitor of metalloproteinase)</span> in <span class='highlight'>Metalloproteinase inhibitor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
![The deposited structure of PDB entry 1buv contains 1 copy of Pfam domain PF00413 (Matrixin) in Matrix metalloproteinase-14. Showing 1 copy in chain A [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_1_M_Pfam_PF00413_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of Pfam domain <span class='highlight'>PF00413 (Matrixin)</span> in <span class='highlight'>Matrix metalloproteinase-14</span>. Showing 1 copy in chain <span class='highlight'>A [auth M]</span>.")
InterPro annotations
Structure domains
CATH domains
3.90.370.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Tissue inhibitor of metalloproteinase-1. Chain B, domain 1
Homology:
Tissue inhibitor of metalloproteinase-1. Chain B, domain 1
Occurring in:
![The deposited structure of PDB entry 1buv contains 1 copy of CATH domain 3.90.370.10 (Tissue inhibitor of metalloproteinase-1. Chain B, domain 1) in Metalloproteinase inhibitor 2. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_2_T_CATH_3.90.370.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of CATH domain <span class='highlight'>3.90.370.10 (Tissue inhibitor of metalloproteinase-1. Chain B, domain 1)</span> in <span class='highlight'>Metalloproteinase inhibitor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
2.40.50.120
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
![The deposited structure of PDB entry 1buv contains 1 copy of CATH domain 2.40.50.120 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Metalloproteinase inhibitor 2. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_2_T_CATH_2.40.50.120_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of CATH domain <span class='highlight'>2.40.50.120 (OB fold (Dihydrolipoamide Acetyltransferase, E2P))</span> in <span class='highlight'>Metalloproteinase inhibitor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
![The deposited structure of PDB entry 1buv contains 1 copy of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Matrix metalloproteinase-14. Showing 1 copy in chain A [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_1_M_CATH_3.40.390.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of CATH domain <span class='highlight'>3.40.390.10 (Collagenase (Catalytic Domain))</span> in <span class='highlight'>Matrix metalloproteinase-14</span>. Showing 1 copy in chain <span class='highlight'>A [auth M]</span>.")
SCOP annotations![The deposited structure of PDB entry 1buv contains 1 copy of SCOP domain 50243 (Tissue inhibitor of metalloproteinases, TIMP) in Metalloproteinase inhibitor 2. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_2_T_SCOP_50243_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of SCOP domain <span class='highlight'>50243 (Tissue inhibitor of metalloproteinases, TIMP)</span> in <span class='highlight'>Metalloproteinase inhibitor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
![The deposited structure of PDB entry 1buv contains 1 copy of SCOP domain 55528 (Matrix metalloproteases, catalytic domain) in Matrix metalloproteinase-14. Showing 1 copy in chain A [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/1buv_1_M_SCOP_55528_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1buv</span> contains 1 copy of SCOP domain <span class='highlight'>55528 (Matrix metalloproteases, catalytic domain)</span> in <span class='highlight'>Matrix metalloproteinase-14</span>. Showing 1 copy in chain <span class='highlight'>A [auth M]</span>.")