› 1bu2

X-ray diffraction
3Å resolution

X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI

Released:
DOI: 10.2210/pdb1bu2/pdb
PDB entry 1bu2 coloured by chain, front view.
PDB entry 1bu2 coloured by chain, side view.
PDB entry 1bu2 coloured by chain, top view.
Source organism: Herpesvirus saimiri (strain 11)
Primary publication:
Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Schulze-Gahmen U, Jung JU, Kim SH
Structure 7 245-54 (1999)
PMID: 10368294

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169508 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin homolog Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.85 KDa
Source organism: Herpesvirus saimiri (strain 11)
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01043 (Residues: 22-250; Coverage: 90%)
Gene names: 72, ECLF2
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P212121
Unit cell:
a: 37.92Å b: 61.44Å c: 130.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.325
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?
Moore et al. (2003)
8 more

1 mention without citation

Hepatoprotective effect of syringin combined with costunolide against LPS-induced acute liver injury in L-02 cells via Rac1/AKT/NF-κB signaling pathway.
Mao et al. (2023)