PDBe 1bu1

X-ray diffraction
2.6Å resolution

SRC FAMILY KINASE HCK SH3 DOMAIN

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase HCK Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 57 amino acids
Theoretical weight: 6.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08631 (Residues: 81-137; Coverage: 11%)
Gene name: HCK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE D2AM
Spacegroup: P21212
Unit cell:
a: 51.5Å b: 106.15Å c: 78.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.297
Expression system: Escherichia coli BL21(DE3)