PDBe 1bsx

X-ray diffraction
3.7Å resolution

STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PROTEIN (GRIP1) Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Synthetic construct
Expression system: Not provided
Thyroid hormone receptor beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 95.2Å b: 95.2Å c: 137.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.249 0.299
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)