1bqh › Citations

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.

Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH
Immunity 9 519-30 (1998)
Cited: 129 times
EuropePMC logo PMID: 9806638

Abstract

The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.

Reviews - 1bqh mentioned but not cited (3)

  1. The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Wang JH, Reinherz EL. Immunol Rev 250 102-119 (2012)
  2. Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment. Li XL, Teng MK, Reinherz EL, Wang JH. Front Immunol 4 383 (2013)
  3. Codification of bidentate pMHC interaction with TCR and its co-receptor. Reinherz EL, Wang JH. Trends Immunol 36 300-306 (2015)

Articles - 1bqh mentioned but not cited (11)

  1. Glycoprotein structural genomics: solving the glycosylation problem. Chang VT, Crispin M, Aricescu AR, Harvey DJ, Nettleship JE, Fennelly JA, Yu C, Boles KS, Evans EJ, Stuart DI, Dwek RA, Jones EY, Owens RJ, Davis SJ. Structure 15 267-273 (2007)
  2. Structural similarity enhances interaction propensity of proteins. Lukatsky DB, Shakhnovich BE, Mintseris J, Shakhnovich EI. J Mol Biol 365 1596-1606 (2007)
  3. Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position. Wang R, Natarajan K, Margulies DH. J Immunol 183 2554-2564 (2009)
  4. Structural mechanism of ER retrieval of MHC class I by cowpox. McCoy WH, Wang X, Yokoyama WM, Hansen TH, Fremont DH. PLoS Biol 10 e1001432 (2012)
  5. Prediction and identification of T cell epitopes in the H5N1 influenza virus nucleoprotein in chicken. Hou Y, Guo Y, Wu C, Shen N, Jiang Y, Wang J. PLoS One 7 e39344 (2012)
  6. A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: Implications for pre-TCR dimerization. Zhou B, Chen Q, Mallis RJ, Zhang H, Zhang H, Liu JH, Reinherz EL, Wang JH. Front Immunol 2 5 (2011)
  7. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. J Mol Biol 384 1190-1202 (2008)
  8. Computational tool for immunotoxic assessment of pyrethroids toward adaptive immune cell receptors. Kumar A, Behera PC, Rangra NK, Dey S, Kant K. Pharmacogn Mag 14 124-128 (2018)
  9. CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells. Souter MNT, Awad W, Li S, Pediongco TJ, Meehan BS, Meehan LJ, Tian Z, Zhao Z, Wang H, Nelson A, Le Nours J, Khandokar Y, Praveena T, Wubben J, Lin J, Sullivan LC, Lovrecz GO, Mak JYW, Liu L, Kostenko L, Kedzierska K, Corbett AJ, Fairlie DP, Brooks AG, Gherardin NA, Uldrich AP, Chen Z, Rossjohn J, Godfrey DI, McCluskey J, Pellicci DG, Eckle SBG. J Exp Med 219 e20210828 (2022)
  10. The structural basis of chicken, swine and bovine CD8αα dimers provides insight into the co-evolution with MHC I in endotherm species. Liu Y, Li X, Qi J, Zhang N, Xia C. Sci Rep 6 24788 (2016)
  11. Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the chicken CD8αα-BF2*0401 complex. Liu Y, Chen R, Tariq M, Xia C. Acta Crystallogr F Struct Biol Commun 70 1264-1267 (2014)


Reviews citing this publication (34)

  1. How TCRs bind MHCs, peptides, and coreceptors. Rudolph MG, Stanfield RL, Wilson IA. Annu Rev Immunol 24 419-466 (2006)
  2. Molecular interactions mediating T cell antigen recognition. van der Merwe PA, Davis SJ. Annu Rev Immunol 21 659-684 (2003)
  3. Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Natarajan K, Dimasi N, Wang J, Mariuzza RA, Margulies DH. Annu Rev Immunol 20 853-885 (2002)
  4. The specificity of TCR/pMHC interaction. Rudolph MG, Wilson IA. Curr Opin Immunol 14 52-65 (2002)
  5. The nature of molecular recognition by T cells. Davis SJ, Ikemizu S, Evans EJ, Fugger L, Bakker TR, van der Merwe PA. Nat Immunol 4 217-224 (2003)
  6. Roles for glycosylation of cell surface receptors involved in cellular immune recognition. Rudd PM, Wormald MR, Stanfield RL, Huang M, Mattsson N, Speir JA, DiGennaro JA, Fetrow JS, Dwek RA, Wilson IA. J Mol Biol 293 351-366 (1999)
  7. Doubting the TCR coreceptor function of CD8alphaalpha. Cheroutre H, Lambolez F. Immunity 28 149-159 (2008)
  8. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Gao GF, Jakobsen BK. Immunol Today 21 630-636 (2000)
  9. Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Gao GF, Rao Z, Bell JI. Trends Immunol 23 408-413 (2002)
  10. Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset. Treiner E, Duban L, Moura IC, Hansen T, Gilfillan S, Lantz O. Microbes Infect 7 552-559 (2005)
  11. Structural and thermodynamic correlates of T cell signaling. Rudolph MG, Luz JG, Wilson IA. Annu Rev Biophys Biomol Struct 31 121-149 (2002)
  12. MHC superfamily structure and the immune system. Maenaka K, Jones EY. Curr Opin Struct Biol 9 745-753 (1999)
  13. Structural basis of T cell recognition of peptides bound to MHC molecules. Wang JH, Reinherz EL. Mol Immunol 38 1039-1049 (2002)
  14. Interactions between MHC molecules and co-receptors of the TCR. König R. Curr Opin Immunol 14 75-83 (2002)
  15. Structural and functional aspects of lipid binding by CD1 molecules. Silk JD, Salio M, Brown J, Jones EY, Cerundolo V. Annu Rev Cell Dev Biol 24 369-395 (2008)
  16. Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer. Strong RK. Mol Immunol 38 1029-1037 (2002)
  17. T-cell allorecognition: a case of mistaken identity or déjà vu? Archbold JK, Macdonald WA, Burrows SR, Rossjohn J, McCluskey J. Trends Immunol 29 220-226 (2008)
  18. The molecular determinants of CD8 co-receptor function. Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK. Immunology 137 139-148 (2012)
  19. TCR-MHC docking orientation: natural selection, or thymic selection? Collins EJ, Riddle DS. Immunol Res 41 267-294 (2008)
  20. Structural basis of cell-cell interactions in the immune system. Wang J, Reinherz EL. Curr Opin Struct Biol 10 656-661 (2000)
  21. MHC class I recognition by Ly49 natural killer cell receptors. Natarajan K, Dimasi N, Wang J, Margulies DH, Mariuzza RA. Mol Immunol 38 1023-1027 (2002)
  22. Structural immunology and crystallography help immunologists see the immune system in action: how T and NK cells touch their ligands. Chen Y, Shi Y, Cheng H, An YQ, Gao GF. IUBMB Life 61 579-590 (2009)
  23. Molecular interactions between extracellular components of the T-cell receptor signaling complex. Garcia KC. Immunol Rev 172 73-85 (1999)
  24. The use of chimeric A2K(b) tetramers to monitor HLA A2 immune responses in HLA A2 transgenic mice. Choi EM, Palmowski M, Chen J, Cerundolo V. J Immunol Methods 268 35-41 (2002)
  25. Co-receptors and recognition of self at the immunological synapse. Gascoigne NR, Zal T, Yachi PP, Hoerter JA. Curr Top Microbiol Immunol 340 171-189 (2010)
  26. Integrating Experiment and Theory to Understand TCR-pMHC Dynamics. Buckle AM, Borg NA. Front Immunol 9 2898 (2018)
  27. Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses. Lederman S, Suciu-Foca N. Hum Immunol 60 533-561 (1999)
  28. Structural and dynamic features of HLA-B27 subtypes. Uchanska-Ziegler B, Ziegler A, Schmieder P. Curr Opin Rheumatol 25 411-418 (2013)
  29. Molecular analysis of protein interactions mediating the function of the cell surface protein CD8. Devine L, Kavathas PB. Immunol Res 19 201-210 (1999)
  30. Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes. Arnaiz-Villena A, Suarez-Trujillo F, Juarez I, Rodríguez-Sainz C, Palacio-Gruber J, Vaquero-Yuste C, Molina-Alejandre M, Fernández-Cruz E, Martin-Villa JM. Cell Mol Life Sci 79 464 (2022)
  31. Regulation of natural killer cell function: a role for the NK cell's own MHC class I molecules. Held W, Chalifour A, Coudert JD. Med Microbiol Immunol 194 169-174 (2005)
  32. Assembling atomic resolution views of the immunological synapse. Wang JH, Eck MJ. Curr Opin Immunol 15 286-293 (2003)
  33. A rational design approach for developing immunomodulators based on CD4 and CD8. Tretiakova AP, Albert RH, Jameson BA. Biotechnol Genet Eng Rev 19 175-203 (2002)
  34. Research progress of nanovaccine in anti-tumor immunotherapy. Yao M, Liu X, Qian Z, Fan D, Sun X, Zhong L, Wu P. Front Oncol 13 1211262 (2023)

Articles citing this publication (81)

  1. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, Bendelac A, Bonneville M, Lantz O. J Exp Med 189 1907-1921 (1999)
  2. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK. Nat Immunol 2 443-451 (2001)
  3. The alphabeta T cell receptor is an anisotropic mechanosensor. Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL. J Biol Chem 284 31028-31037 (2009)
  4. Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms. Reche PA, Reinherz EL. J Mol Biol 331 623-641 (2003)
  5. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Tormo J, Natarajan K, Margulies DH, Mariuzza RA. Nature 402 623-631 (1999)
  6. T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics. Wyer JR, Willcox BE, Gao GF, Gerth UC, Davis SJ, Bell JI, van der Merwe PA, Jakobsen BK. Immunity 10 219-225 (1999)
  7. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A, Reinherz EL. Proc Natl Acad Sci U S A 98 10799-10804 (2001)
  8. Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding. Moody AM, Chui D, Reche PA, Priatel JJ, Marth JD, Reinherz EL. Cell 107 501-512 (2001)
  9. Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Proc Natl Acad Sci U S A 112 1517-1522 (2015)
  10. CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Daniels MA, Devine L, Miller JD, Moser JM, Lukacher AE, Altman JD, Kavathas P, Hogquist KA, Jameson SC. Immunity 15 1051-1061 (2001)
  11. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price DA, Sewell AK. J Biol Chem 280 27491-27501 (2005)
  12. Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J. Immunity 27 885-899 (2007)
  13. Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination. Jiang N, Huang J, Edwards LJ, Liu B, Zhang Y, Beal CD, Evavold BD, Zhu C. Immunity 34 13-23 (2011)
  14. CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, Taurog JD. J Immunol 170 1099-1105 (2003)
  15. Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Potter TA, Grebe K, Freiberg B, Kupfer A. Proc Natl Acad Sci U S A 98 12624-12629 (2001)
  16. Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA. Nat Immunol 4 1213-1222 (2003)
  17. Structure-based prediction of binding peptides to MHC class I molecules: application to a broad range of MHC alleles. Schueler-Furman O, Altuvia Y, Sette A, Margalit H. Protein Sci 9 1838-1846 (2000)
  18. A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection. Buslepp J, Wang H, Biddison WE, Appella E, Collins EJ. Immunity 19 595-606 (2003)
  19. Biochemical features of the MHC-related protein 1 consistent with an immunological function. Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L. J Immunol 170 6090-6098 (2003)
  20. Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus. Bosselut R, Kubo S, Guinter T, Kopacz JL, Altman JD, Feigenbaum L, Singer A. Immunity 12 409-418 (2000)
  21. The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Glaser F, Rosenberg Y, Kessel A, Pupko T, Ben-Tal N. Proteins 58 610-617 (2005)
  22. Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8. Taurog JD, Dorris ML, Satumtira N, Tran TM, Sharma R, Dressel R, van den Brandt J, Reichardt HM. Arthritis Rheum 60 1977-1984 (2009)
  23. The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH. Immunity 18 205-215 (2003)
  24. Kinetics of MHC-CD8 interaction at the T cell membrane. Huang J, Edwards LJ, Evavold BD, Zhu C. J Immunol 179 7653-7662 (2007)
  25. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand. Matsumoto N, Mitsuki M, Tajima K, Yokoyama WM, Yamamoto K. J Exp Med 193 147-158 (2001)
  26. High avidity antigen-specific CTL identified by CD8-independent tetramer staining. Choi EM, Chen JL, Wooldridge L, Salio M, Lissina A, Lissin N, Hermans IF, Silk JD, Mirza F, Palmowski MJ, Dunbar PR, Jakobsen BK, Sewell AK, Cerundolo V. J Immunol 171 5116-5123 (2003)
  27. The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. Chervin AS, Stone JD, Holler PD, Bai A, Chen J, Eisen HN, Kranz DM. J Immunol 183 1166-1178 (2009)
  28. Structures of PD-1 with its ligands: sideways and dancing cheek to cheek. Freeman GJ. Proc Natl Acad Sci U S A 105 10275-10276 (2008)
  29. Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Li Y, Yin Y, Mariuzza RA. Front Immunol 4 206 (2013)
  30. Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation. He X, Tabaczewski P, Ho J, Stroynowski I, Garcia KC. Structure 9 1213-1224 (2001)
  31. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. Boucherma R, Kridane-Miledi H, Bouziat R, Rasmussen M, Gatard T, Langa-Vives F, Lemercier B, Lim A, Bérard M, Benmohamed L, Buus S, Rooke R, Lemonnier FA. J Immunol 191 583-593 (2013)
  32. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide. Mareeva T, Martinez-Hackert E, Sykulev Y. J Biol Chem 283 29053-29059 (2008)
  33. Structure of a pheromone receptor-associated MHC molecule with an open and empty groove. Olson R, Huey-Tubman KE, Dulac C, Bjorkman PJ. PLoS Biol 3 e257 (2005)
  34. The CD8alpha from sea bass (Dicentrarchus labrax L.): Cloning, expression and 3D modelling. Buonocore F, Randelli E, Bird S, Secombes CJ, Costantini S, Facchiano A, Mazzini M, Scapigliati G. Fish Shellfish Immunol 20 637-646 (2006)
  35. The CD8alphabeta co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci. Moody AM, Xiong Y, Chang HC, Reinherz EL. Eur J Immunol 31 2791-2799 (2001)
  36. Coreceptor CD8-driven modulation of T cell antigen receptor specificity. van den Berg HA, Wooldridge L, Laugel B, Sewell AK. J Theor Biol 249 395-408 (2007)
  37. Force measurements of TCR/pMHC recognition at T cell surface. Puech PH, Nevoltris D, Robert P, Limozin L, Boyer C, Bongrand P. PLoS One 6 e22344 (2011)
  38. Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH. Immunity 23 661-671 (2005)
  39. Crystal structure of the murine cytomegalovirus MHC-I homolog m144. Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH. J Mol Biol 358 157-171 (2006)
  40. High affinity xenoreactive TCR:MHC interaction recruits CD8 in absence of binding to MHC. Buslepp J, Kerry SE, Loftus D, Frelinger JA, Appella E, Collins EJ. J Immunol 170 373-383 (2003)
  41. CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice. Zhong W, Reinherz EL. Eur J Immunol 35 3103-3110 (2005)
  42. Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes. Bennett MS, Joseph A, Ng HL, Goldstein H, Yang OO. AIDS 24 2619-2628 (2010)
  43. Supine orientation of a murine MHC class I molecule on the membrane bilayer. Mitra AK, Célia H, Ren G, Luz JG, Wilson IA, Teyton L. Curr Biol 14 718-724 (2004)
  44. The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains. Devine L, Rogozinski L, Naidenko OV, Cheroutre H, Kavathas PB. J Immunol 168 3881-3886 (2002)
  45. Plasticity of human CD8αα binding to peptide-HLA-A*2402. Shi Y, Qi J, Iwamoto A, Gao GF. Mol Immunol 48 2198-2202 (2011)
  46. Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin. Achour A, Michaëlsson J, Harris RA, Ljunggren HG, Kärre K, Schneider G, Sandalova T. J Mol Biol 356 382-396 (2006)
  47. Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer. Devine L, Kieffer LJ, Aitken V, Kavathas PB. J Immunol 164 833-838 (2000)
  48. Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species. Dijkstra JM, Yamaguchi T, Grimholt U. Immunogenetics 70 459-476 (2018)
  49. MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Wooldridge L, Clement M, Lissina A, Edwards ES, Ladell K, Ekeruche J, Hewitt RE, Laugel B, Gostick E, Cole DK, Debets R, Berrevoets C, Miles JJ, Burrows SR, Price DA, Sewell AK. J Immunol 184 3357-3366 (2010)
  50. Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules. Hee CS, Beerbaum M, Loll B, Ballaschk M, Schmieder P, Uchanska-Ziegler B, Ziegler A. Immunogenetics 65 157-172 (2013)
  51. The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice. Holler PD, Yamagata T, Jiang W, Feuerer M, Benoist C, Mathis D. Proc Natl Acad Sci U S A 104 7187-7192 (2007)
  52. Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Devine L, Hodsdon ME, Daniels MA, Jameson SC, Kavathas PB. Immunol Lett 93 123-130 (2004)
  53. Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding. Devine L, Thakral D, Nag S, Dobbins J, Hodsdon ME, Kavathas PB. J Immunol 177 3930-3938 (2006)
  54. Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells. Lee PU, Kranz DM. Mol Immunol 39 687-695 (2003)
  55. Molecular cloning and characterization of sea bass (Dicentrarchus labrax, L.) MHC class I heavy chain and β2-microglobulin. Pinto RD, Randelli E, Buonocore F, Pereira PJ, dos Santos NM. Dev Comp Immunol 39 234-254 (2013)
  56. The sequence signature of an Ig-fold. Wang JH. Protein Cell 4 569-572 (2013)
  57. The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. Kao C, Sandau MM, Daniels MA, Jameson SC. J Immunol 176 7421-7430 (2006)
  58. Construction of bioactive chimeric MHC class I tetramer by expression and purification of human-murine chimeric MHC heavy chain and beta(2)m as a fusion protein in Escherichia coli. Ren D, Wang F, He X, Jiang L, Li D, Ying H, Sun S. Protein Expr Purif 50 171-178 (2006)
  59. Characterization of arrangement and expression of the beta-2 microglobulin locus in the sandbar and nurse shark. Chen H, Kshirsagar S, Jensen I, Lau K, Simonson C, Schluter SF. Dev Comp Immunol 34 189-195 (2010)
  60. Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin. Sandalova T, Michaëlsson J, Harris RA, Ljunggren HG, Kärre K, Schneider G, Achour A. Acta Crystallogr Sect F Struct Biol Cryst Commun 61 1090-1093 (2005)
  61. Rapid rejection of HLA-A2 transgenic skin graft due to indirect allorecognition. Jurcevic S, Chandler P, Sacks SH, Simpson E. Transplantation 72 994-997 (2001)
  62. The murine CD94/NKG2 ligand, Qa-1b, is a high-affinity, functional ligand for the CD8αα homodimer. Goodall KJ, Nguyen A, McKenzie C, Eckle SBG, Sullivan LC, Andrews DM. J Biol Chem 295 3239-3246 (2020)
  63. Genomic organization of the chicken CD8 locus reveals a novel family of immunoreceptor genes. Liaw HJ, Chen WR, Huang YC, Tsai CW, Chang KC, Kuo CL. J Immunol 178 3023-3030 (2007)
  64. Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development. Goodall KJ, Nguyen A, Matsumoto A, McMullen JR, Eckle SB, Bertolino P, Sullivan LC, Andrews DM. Immunol Cell Biol 97 326-339 (2019)
  65. Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution. Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA. J Mol Biol 358 347-354 (2006)
  66. Molecular modelling of co-receptor CD8 alpha alpha and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata). Costantini S, Buonocore F, Facchiano AM. Fish Shellfish Immunol 25 782-790 (2008)
  67. T-cell differentiation: MHC class I's sweet tooth lost on maturity. Gascoigne NR. Curr Biol 12 R99-R101 (2002)
  68. Xenogeneic beta 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells. Benoit LA, Tan R. J Immunol 179 3588-3595 (2007)
  69. The marsupial CD8 gene locus: molecular cloning and expression analysis of the alpha and beta sequences in the gray short-tailed opossum (Monodelphis domestica) and the tammar wallaby (Macropus eugenii). Duncan LG, Nair SV, Deane EM. Vet Immunol Immunopathol 129 14-27 (2009)
  70. An essential role for the stalk region of CD8 beta in the coreceptor function of CD8. Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, Kioussis D, Zamoyska R. J Immunol 182 121-129 (2009)
  71. Interactions between CD8alphabeta and the TCRalphabeta/CD3-receptor complex. Rubin B, Riond J, Leghait J, Gairin JE. Scand J Immunol 64 260-270 (2006)
  72. Macrophage migration inhibitory factor has a MHC class I-like motif and function. Gibbings DJ, Ghetu AF, Dery R, Befus AD. Scand J Immunol 67 121-132 (2008)
  73. Rational design of cytotoxic T-cell inhibitors. Tretiakova AP, Little CS, Blank KJ, Jameson BA. Nat Biotechnol 18 984-988 (2000)
  74. Rhesus macaque: a tight homodimeric CD8alphaalpha. Zong L, Chen Y, Peng H, Gao F, Iwamoto A, Gao GF. Proteins 75 241-244 (2009)
  75. TCR complex-activated CD8 adhesion function by human T cells. Varghese JC, Kane KP. J Immunol 181 6002-6009 (2008)
  76. The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response. Liu Y, Chen R, Liang R, Sun B, Wu Y, Zhang L, Kaufman J, Xia C. Front Immunol 11 605085 (2020)
  77. Expression and purification of antigenically active soluble derivatives of the heterodimeric and homodimeric forms of the mouse CD8 lymphocyte membrane glycoprotein. Pellicci DG, Kortt AA, Sparrow LG, Hudson PJ, Sorensen HV, Davis SJ, Classon BJ. J Immunol Methods 246 149-163 (2000)
  78. An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation. Kang YJ, Wang X, Lin SJ, Hsu YM, Chang HC. Eur J Immunol 40 836-848 (2010)
  79. Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor. Ma J, Ayres CM, Hellman LM, Devlin JR, Baker BM. J Biol Chem 296 100686 (2021)
  80. Structural analysis of H2-Db class I molecules containing two different allelic forms of the type 1 diabetes susceptibility factor beta-2 microglobulin: implications for the mechanism underlying variations in antigen presentation. Roden MM, Brims DR, Fedorov AA, DiLorenzo TP, Almo SC, Nathenson SG. Mol Immunol 43 1370-1378 (2006)
  81. Expression, purification, crystallization and preliminary X-ray diffraction analysis of rhesus macaque CD8alphaalpha homodimer. Zong L, Chen Y, Yan J, Zhang J. Acta Crystallogr Sect F Struct Biol Cryst Commun 66 435-438 (2010)


Quick links