PDBe 1bnd

X-ray diffraction
2.3Å resolution

STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR(SLASH)NEUROTROPHIN 3 HETERODIMER

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurotrophin-3 Chain: B
Molecule details ›
Chain: B
Length: 119 amino acids
Theoretical weight: 13.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20783 (Residues: 139-257; Coverage: 50%)
Gene name: NTF3
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Brain-derived neurotrophic factor Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23560 (Residues: 129-247; Coverage: 52%)
Gene name: BDNF
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 98.4Å b: 45.1Å c: 68Å
α: 90° β: 118.3° γ: 90°
R-values:
R R work R free
0.182 0.182 not available
Expression system: Escherichia coli