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COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE

Source organisms:
Biochemical function: serine-type endopeptidase activity
Biological process: plasminogen activation
Cellular component: extracellular region

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EC 3.4.21.7: Plasmin

Reaction catalysed:
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Systematic name:
-
Alternative Name(s):
  • Actase
  • Fibrinase
  • Fibrinolysin
  • Serum tryptase
  • Thrombolysin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02821
Domain description: Staphylokinase/Streptokinase family
Occurring in:
  1. Streptokinase C
The deposited structure of PDB entry 1bml contains 2 copies of Pfam domain PF02821 (Staphylokinase/Streptokinase family) in Streptokinase C. Showing 1 copy in chain C.

PF00089
Domain description: Trypsin
Occurring in:
  1. Plasmin light chain B
The deposited structure of PDB entry 1bml contains 2 copies of Pfam domain PF00089 (Trypsin) in Plasmin light chain B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008124
Domain description: Streptokinase
Occurring in:
  1. Streptokinase C
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Plasmin light chain B
IPR036120
Domain description: Staphylokinase/Streptokinase superfamily
Occurring in:
  1. Streptokinase C
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Plasmin light chain B
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Plasmin light chain B
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Plasmin light chain B
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Plasmin light chain B

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Plasmin light chain B
The deposited structure of PDB entry 1bml contains 4 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Plasmin light chain B. Showing 2 copies in chain A.
3.10.20.180
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Streptokinase C
The deposited structure of PDB entry 1bml contains 4 copies of CATH domain 3.10.20.180 (Ubiquitin-like (UB roll)) in Streptokinase C. Showing 2 copies in chain C.
3.10.20.150
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Streptokinase C
The deposited structure of PDB entry 1bml contains 2 copies of CATH domain 3.10.20.150 (Ubiquitin-like (UB roll)) in Streptokinase C. Showing 1 copy in chain C.
SCOP SCOP annotations
54329
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Staphylokinase/streptokinase
Occurring in:
  1. Streptokinase C
The deposited structure of PDB entry 1bml contains 6 copies of SCOP domain 54329 (Staphylokinase/streptokinase) in Streptokinase C. Showing 3 copies in chain C.
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Plasmin light chain B
The deposited structure of PDB entry 1bml contains 2 copies of SCOP domain 50514 (Eukaryotic proteases) in Plasmin light chain B. Showing 1 copy in chain A.

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