PDBe 1bmb

X-ray diffraction
1.8Å resolution

GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PROTEIN (PKF270-974) Chain: I
Molecule details ›
Chain: I
Length: 9 amino acids
Theoretical weight: 1.22 KDa
Source organism: Synthetic construct
Expression system: Not provided
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 49-168; Coverage: 55%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P41212
Unit cell:
a: 51.13Å b: 51.13Å c: 90.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.218
Expression systems:
  • Not provided
  • Escherichia coli