› 1bik

X-ray diffraction
2.5Å resolution

X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX

Released:
DOI: 10.2210/pdb1bik/pdb
PDB entry 1bik coloured by chain, front view.
PDB entry 1bik coloured by chain, side view.
PDB entry 1bik coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains.
Xu Y, Carr PD, Guss JM, Ollis DL
J Mol Biol 276 955-66 (1998)
PMID: 9566199

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inter-alpha-trypsin inhibitor light chain Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 15.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02760 (Residues: 206-352; Coverage: 44%)
Gene names: AMBP, HCP, ITIL
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P41212
Unit cell:
a: 55.3Å b: 55.3Å c: 146.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.253

Quick links

Citations

6 review citations

Bikunin--not just a plasma proteinase inhibitor.
Fries et al. (2000)
5 more

15 mentions without citation

A pathogenic nematode targets recognition proteins to avoid insect defenses.
Toubarro et al. (2013)
14 more