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Transition state structure of arginine kinase: implications for catalysis of bimolecular reactions.

Proc. Natl. Acad. Sci. U.S.A. 95 8449-54 (1998)
Cited: 140 times
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Arginine kinase belongs to the family of enzymes, including creatine kinase, that catalyze the buffering of ATP in cells with fluctuating energy requirements and that has been a paradigm for classical enzymological studies. The 1.86-A resolution structure of its transition-state analog complex, reported here, reveals its active site and offers direct evidence for the importance of precise substrate alignment in the catalysis of bimolecular reactions, in contrast to the unimolecular reactions studied previously. In the transition-state analog complex studied here, a nitrate mimics the planar gamma-phosphoryl during associative in-line transfer between ATP and arginine. The active site is unperturbed, and the reactants are not constrained covalently as in a bisubstrate complex, so it is possible to measure how precisely they are pre-aligned by the enzyme. Alignment is exquisite. Entropic effects may contribute to catalysis, but the lone-pair orbitals are also aligned close enough to their optimal trajectories for orbital steering to be a factor during nucleophilic attack. The structure suggests that polarization, strain toward the transition state, and acid-base catalysis also contribute, but, in contrast to unimolecular enzyme reactions, their role appears to be secondary to substrate alignment in this bimolecular reaction.

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  1. Chemical biology of protein arginine modifications in epigenetic regulation. Fuhrmann J, Clancy KW, Thompson PR. Chem Rev 115 5413-5461 (2015)

Articles - 1bg0 mentioned but not cited (14)

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Reviews citing this publication (3)

  1. Geometry of nonbonded interactions involving planar groups in proteins. Chakrabarti P, Bhattacharyya R. Prog Biophys Mol Biol 95 83-137 (2007)
  2. Relating structure to mechanism in creatine kinase. McLeish MJ, Kenyon GL. Crit Rev Biochem Mol Biol 40 1-20 (2005)
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