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TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX

X-ray diffraction
2.9Å resolution
PDB entry 1bf5 coloured by chain, front view.
PDB entry 1bf5 coloured by chain, side view.
PDB entry 1bf5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: STAT1 homodimer and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 56146.19 Å2
Buried surface area: 7245.1 Å2
Dissociation area: 1,569.87 Å2
Dissociation energy (ΔGdiss): 27.89 kcal/mol
Dissociation entropy (TΔSdiss): 12.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-218897

Macromolecules

Signal transducer and activator of transcription 1-alpha/beta
Chain: A
Length: 575 amino acids
Theoretical weight: 66.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42224 (Residues: 136-710; Coverage: 77%)
Gene name: STAT1
Pfam:
InterPro:
CATH:
SCOP:
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1bf5, assembly 1, front view.
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1bf5, assembly 1, side view.
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1bf5, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3')
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Escherichia coli BL21 [511693]
Length: 18 nucleotides
Theoretical weight: 5.48 KDa
DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3') in PDB entry 1bf5, assembly 1, front view.
DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3') in PDB entry 1bf5, assembly 1, side view.
DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3') in PDB entry 1bf5, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3')
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.56 KDa
DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3') in PDB entry 1bf5, assembly 1, front view.
DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3') in PDB entry 1bf5, assembly 1, side view.
DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3') in PDB entry 1bf5, assembly 1, top view.
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