PDBe 1b6b

X-ray diffraction
2.5Å resolution

MELATONIN BIOSYNTHESIS: THE STRUCTURE OF SEROTONIN N-ACETYLTRANSFERASE AT 2.5 A RESOLUTION SUGGESTS A CATALYTIC MECHANISM

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine. 
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotonin N-acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 174 amino acids
Theoretical weight: 19.56 KDa
Source organism: Ovis aries
Expression system: Escherichia coli
UniProt:
  • Canonical: Q29495 (Residues: 28-201; Coverage: 84%)
Gene names: AANAT, SNAT
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P61
Unit cell:
a: 56.61Å b: 56.61Å c: 207.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.282
Expression system: Escherichia coli