Function and Biology

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Source organism: Rattus rattus
Biochemical function: identical protein binding
Biological process: tetrahydrobiopterin biosynthetic process
Cellular component: cellular_component

EC 4.2.3.12: 6-pyruvoyltetrahydropterin synthase

Reaction catalysed:
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Systematic name:
7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
Alternative Name(s):
  • PTPS
  • 6-pyruvoyl tetrahydrobiopterin synthase
  • 2-amino-4-oxo-6-((1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydroxypteridine triphosphate lyase
  • 6-((1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)

Sequence family

Pfam Protein family (Pfam)
PF01242
Domain description: 6-pyruvoyl tetrahydropterin synthase
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
1 copy of Pfam domain PF01242 (6-pyruvoyl tetrahydropterin synthase) in 6-pyruvoyl tetrahydrobiopterin synthase in PDB 1b66.

InterPro InterPro annotations
IPR007115
Domain description: 6-pyruvoyl tetrahydropterin synthase/QueD family
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
IPR038418
Domain description: 6-pyruvoyl tetrahydropterin synthase/QueD superfamily
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
IPR022469
Domain description: 6-pyruvoyl tetrahydropterin synthase, histidine active site
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
IPR022470
Domain description: 6-pyruvoyl tetrahydropterin synthase, cysteine active site
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase

Structure domain

CATH CATH domain
3.30.479.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Tetrahydropterin Synthase; Chain A
Homology: Tetrahydropterin Synthase; Chain A
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
1 copy of CATH domain 3.30.479.10 (Tetrahydropterin Synthase; Chain A) in 6-pyruvoyl tetrahydrobiopterin synthase in PDB 1b66.
SCOP SCOP annotation
55625
Class: Alpha and beta proteins (a+b)
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Occurring in:
  1. 6-pyruvoyl tetrahydrobiopterin synthase
1 copy of SCOP domain 55625 (6-pyruvoyl tetrahydropterin synthase) in 6-pyruvoyl tetrahydrobiopterin synthase in PDB 1b66.