Function and Biology

CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE IN COMPLEX WITH PHOSPHOGLYCOLOHYDROXAMATE

Source organism: Escherichia coli
Biochemical function: zinc ion binding
Biological process: glycolytic process
Cellular component: cytosol

EC 4.1.2.13: Fructose-bisphosphate aldolase

Reaction catalysed:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Comments:
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
Systematic name:
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
Alternative Name(s):
  • 1,6-diphosphofructose aldolase
  • SMALDO
  • Aldolase
  • Diphosphofructose aldolase
  • Fructoaldolase
  • Fructose 1,6-diphosphate aldolase
  • Fructose 1-monophosphate aldolase
  • Fructose 1-phosphate aldolase
  • Fructose diphosphate aldolase
  • Fructose-1,6-bisphosphate triosephosphate-lyase
  • Ketose 1-phosphate aldolase
  • Phosphofructoaldolase
  • Zymohexase
  • D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase

Sequence family

CATH Protein family (Pfam)
PF01116
Domain description: Fructose-bisphosphate aldolase class-II
Occurring in:
  1. Fructose-bisphosphate aldolase class 2
1 copy of Pfam domain PF01116 (Fructose-bisphosphate aldolase class-II) in Fructose-bisphosphate aldolase class 2 in PDB 1b57.

CATH InterPro annotations
IPR000771
Domain description: Fructose-bisphosphate aldolase, class-II
Occurring in:
  1. Fructose-bisphosphate aldolase class 2
IPR006411
Domain description: Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype
Occurring in:
  1. Fructose-bisphosphate aldolase class 2
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Fructose-bisphosphate aldolase class 2

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Fructose-bisphosphate aldolase class 2
1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Fructose-bisphosphate aldolase class 2 in PDB 1b57.
SCOP SCOP annotation
51591
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. Fructose-bisphosphate aldolase class 2
1 copy of SCOP domain 51591 (Class II FBP aldolase) in Fructose-bisphosphate aldolase class 2 in PDB 1b57.