Function and Biology

RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE

Source organism: Rattus norvegicus
Biochemical function: adenyl nucleotide binding
Biological process: S-adenosylmethionine cycle
Cellular component: extracellular exosome

EC 3.3.1.1: Adenosylhomocysteinase

Reaction catalysed:
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
Comments:
  • The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.
Systematic name:
S-adenosyl-L-homocysteine hydrolase
Alternative Name(s):
  • S-adenosylhomocysteinase
  • S-adenosylhomocysteine hydrolase
  • S-adenosylhomocysteine synthase
  • AdoHcyase
  • SAHase
  • Adenosylhomocysteine hydrolase

Sequence families

CATH Protein families (Pfam)
PF05221
Domain description: S-adenosyl-L-homocysteine hydrolase
Occurring in:
  1. Adenosylhomocysteinase
2 copies of Pfam domain PF05221 (S-adenosyl-L-homocysteine hydrolase) in Adenosylhomocysteinase in PDB 1b3r.

PF02826
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase
1 copy of Pfam domain PF02826 (D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) in Adenosylhomocysteinase in PDB 1b3r.

PF07991
Domain description: Acetohydroxy acid isomeroreductase, NADPH-binding domain
Occurring in:
  1. Adenosylhomocysteinase
1 copy of Pfam domain PF07991 (Acetohydroxy acid isomeroreductase, NADPH-binding domain) in Adenosylhomocysteinase in PDB 1b3r.

PF00670
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase
1 copy of Pfam domain PF00670 (S-adenosyl-L-homocysteine hydrolase, NAD binding domain) in Adenosylhomocysteinase in PDB 1b3r.

CATH InterPro annotations
IPR000043
Domain description: Adenosylhomocysteinase-like
Occurring in:
  1. Adenosylhomocysteinase
IPR020082
Domain description: S-adenosyl-L-homocysteine hydrolase, conserved site
Occurring in:
  1. Adenosylhomocysteinase
IPR015878
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase
IPR016040
Domain description: NAD(P)-binding domain
Occurring in:
  1. Adenosylhomocysteinase
IPR034373
Domain description: Adenosylhomocysteinase
Occurring in:
  1. Adenosylhomocysteinase

Structure domains

CATH CATH domains
3.40.50.1480
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Adenosylhomocysteinase
1 copy of CATH domain 3.40.50.1480 (Rossmann fold) in Adenosylhomocysteinase in PDB 1b3r.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Adenosylhomocysteinase
1 copy of CATH domain 3.40.50.720 (Rossmann fold) in Adenosylhomocysteinase in PDB 1b3r.
SCOP SCOP annotations
52300
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Formate/glycerate dehydrogenase catalytic domain-like
Occurring in:
  1. Adenosylhomocysteinase
1 copy of SCOP domain 52300 (S-adenosylhomocystein hydrolase) in Adenosylhomocysteinase in PDB 1b3r.
51830
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Adenosylhomocysteinase
1 copy of SCOP domain 51830 (Formate/glycerate dehydrogenases, NAD-domain) in Adenosylhomocysteinase in PDB 1b3r.