› › Structure analysis

PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES)

X-ray diffraction
1.8Å resolution
PDB entry 1b2b coloured by chain, front view.
PDB entry 1b2b coloured by chain, side view.
PDB entry 1b2b coloured by chain, top view.
Source organism: Sus scrofa
Assemblies composition:
hetero dimer (preferred)
hetero hexamer
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Insulin B chain
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 3484.42 Å2
Buried surface area: 1653.66 Å2
Dissociation area: 770.65 Å2
Dissociation energy (ΔGdiss): 8.77 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 2
Download    3D Visualisation
Assembly Name: Insulin B chain
hide full assembly name
Multimeric state: hetero hexamer
Accessible surface area: 8534.99 Å2
Buried surface area: 6881.08 Å2
Dissociation area: 2,631.55 Å2
Dissociation energy (ΔGdiss): 30.45 kcal/mol
Dissociation entropy (TΔSdiss): 25.94 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245
Assembly 3
Download    3D Visualisation
Assembly Name: Insulin B chain
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 5735.11 Å2
Buried surface area: 4540.76 Å2
Dissociation area: 618.41 Å2
Dissociation energy (ΔGdiss): 0.85 kcal/mol
Dissociation entropy (TΔSdiss): 9.56 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1b2b, assembly 1, front view.
Insulin A chain in PDB entry 1b2b, assembly 1, side view.
Insulin A chain in PDB entry 1b2b, assembly 1, top view.
Molecule details ›

Search similar proteins

Insulin B chain
Chain: B
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 25-54; Coverage: 36%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1b2b, assembly 1, front view.
Insulin B chain in PDB entry 1b2b, assembly 1, side view.
Insulin B chain in PDB entry 1b2b, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links