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CRYSTAL STRUCTURE OF TYPE 1 SIGNAL PEPTIDASE FROM ESCHERICHIA COLI IN COMPLEX WITH A BETA-LACTAM INHIBITOR

X-ray diffraction
1.95Å resolution
PDB entry 1b12 coloured by chain, front view.
PDB entry 1b12 coloured by chain, side view.
PDB entry 1b12 coloured by chain, top view.
Source organism: Escherichia coli BL21(DE3)
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Signal peptidase I
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Multimeric state: monomeric
Accessible surface area: 12429.77 Å2
Buried surface area: 549.97 Å2
Dissociation area: 274.98 Å2
Dissociation energy (ΔGdiss): -1.34 kcal/mol
Dissociation entropy (TΔSdiss): 3.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133584
Assembly 2 (preferred)
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Assembly Name: Signal peptidase I
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Multimeric state: monomeric
Accessible surface area: 10735.43 Å2
Buried surface area: 669.86 Å2
Dissociation area: 58.83 Å2
Dissociation energy (ΔGdiss): 2.25 kcal/mol
Dissociation entropy (TΔSdiss): 0.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133584
Assembly 3
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Assembly Name: Signal peptidase I
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Multimeric state: monomeric
Accessible surface area: 11545.59 Å2
Buried surface area: 544.76 Å2
Dissociation area: 272.38 Å2
Dissociation energy (ΔGdiss): -1.12 kcal/mol
Dissociation entropy (TΔSdiss): 3.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133584
Assembly 4
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Assembly Name: Signal peptidase I
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Multimeric state: monomeric
Accessible surface area: 11611.27 Å2
Buried surface area: 552.09 Å2
Dissociation area: 276.04 Å2
Dissociation energy (ΔGdiss): -0.98 kcal/mol
Dissociation entropy (TΔSdiss): 3.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133584

Macromolecules

Signal peptidase I
Chains: A, B, C, D
Length: 248 amino acids
Theoretical weight: 27.84 KDa
Source organism: Escherichia coli BL21(DE3)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00803 (Residues: 77-324; Coverage: 77%)
Gene names: JW2552, b2568, lepB
Pfam: Signal peptidase, peptidase S26
InterPro:
CATH:
SCOP: Type 1 signal peptidase
Signal peptidase I in PDB entry 1b12, assembly 2, front view.
Signal peptidase I in PDB entry 1b12, assembly 2, side view.
Signal peptidase I in PDB entry 1b12, assembly 2, top view.
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