Function and Biology

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Comments:
  • Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • (Phosphotyrosine)protein phosphatase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

CATH Protein family (Pfam)
PF00017
Domain description: SH2 domain
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 11
1 copy of Pfam domain PF00017 (SH2 domain) in Tyrosine-protein phosphatase non-receptor type 11 in PDB 1ayd.

CATH InterPro annotation
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 11

Structure domain

CATH CATH domain
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SHC Adaptor Protein
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 11
1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Tyrosine-protein phosphatase non-receptor type 11 in PDB 1ayd.
SCOP SCOP annotation
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 11
1 copy of SCOP domain 55551 (SH2 domain) in Tyrosine-protein phosphatase non-receptor type 11 in PDB 1ayd.