PDBe 1ayc

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Released:

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Platelet-derived growth factor receptor beta Chain: P
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.23 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P05622 (Residues: 736-744; Coverage: 1%)
Gene names: Pdgfr, Pdgfr1, Pdgfrb
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.53 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P35235 (Residues: 4-103; Coverage: 17%)
Gene name: Ptpn11
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 62.2Å b: 62.2Å c: 74.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 not available
Expression system: Not provided