EC 3.4.23.3: Gastricsin
Reaction catalysed:
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|- bonds. High activity on hemoglobin.
Alternative Name(s):
- Parapepsin II
- Pepsin C
- Pig parapepsin II
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Protein families (Pfam)![The deposited structure of PDB entry 1avf contains 2 copies of Pfam domain PF07966 (A1 Propeptide) in Gastricsin. Showing 1 copy in chain C [auth Q].](https://www.ebi.ac.uk/pdbe/static/entry/1avf_1_Q_Pfam_PF07966_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1avf</span> contains 2 copies of Pfam domain <span class='highlight'>PF07966 (A1 Propeptide)</span> in <span class='highlight'>Gastricsin</span>. Showing 1 copy in chain <span class='highlight'>C [auth Q]</span>.")
![The deposited structure of PDB entry 1avf contains 2 copies of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Gastricsin. Showing 1 copy in chain D [auth J].](https://www.ebi.ac.uk/pdbe/static/entry/1avf_2_J_Pfam_PF00026_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1avf</span> contains 2 copies of Pfam domain <span class='highlight'>PF00026 (Eukaryotic aspartyl protease)</span> in <span class='highlight'>Gastricsin</span>. Showing 1 copy in chain <span class='highlight'>D [auth J]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 1avf contains 4 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Gastricsin. Showing 2 copies in chain D [auth J].](https://www.ebi.ac.uk/pdbe/static/entry/1avf_2_J_CATH_2.40.70.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1avf</span> contains 4 copies of CATH domain <span class='highlight'>2.40.70.10 (Cathepsin D, subunit A; domain 1)</span> in <span class='highlight'>Gastricsin</span>. Showing 2 copies in chain <span class='highlight'>D [auth J]</span>.")
SCOP annotation![The deposited structure of PDB entry 1avf contains 2 copies of SCOP domain 50646 (Pepsin-like) in Gastricsin. Showing 1 copy in chain D [auth J].](https://www.ebi.ac.uk/pdbe/static/entry/1avf_2_J_SCOP_50646_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1avf</span> contains 2 copies of SCOP domain <span class='highlight'>50646 (Pepsin-like)</span> in <span class='highlight'>Gastricsin</span>. Showing 1 copy in chain <span class='highlight'>D [auth J]</span>.")