PDBe 1avf

X-ray diffraction
2.36Å resolution

ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH

Released:

Function and Biology Details

Reaction catalysed:
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gastricsin Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 26 amino acids
Theoretical weight: 2.98 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P20142 (Residues: 17-42; Coverage: 7%)
Gene name: PGC
Gastricsin Chains: A, J
Molecule details ›
Chains: A, J
Length: 329 amino acids
Theoretical weight: 35.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P20142 (Residues: 60-388; Coverage: 88%)
Gene name: PGC
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG
Spacegroup: C2
Unit cell:
a: 156.26Å b: 50.41Å c: 125.18Å
α: 90° β: 117.62° γ: 90°
R-values:
R R work R free
0.227 0.227 0.282