Function and Biology

Human activated protein C

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.21.69: Protein C (activated)

Reaction catalysed:
Degradation of blood coagulation factors Va and VIIIa.
Comments:
  • One of the gamma-carboxyglutamic acid-containing coagulation factors.
  • Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms.
  • Belongs to peptidase family S1.
Systematic name:
-
Alternative Name(s):
  • APC
  • GSAPC
  • Activated blood coagulation factor XIV
  • Activated protein C
  • Autoprothrombin II-A
  • Blood-coagulation factor XIVa
  • Protein Ca
  • Autoprothrombin IIA

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

CATH Protein families (Pfam)
PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Vitamin K-dependent protein C light chain
1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Vitamin K-dependent protein C light chain in PDB 1aut.

PF00008
Domain description: EGF-like domain
Occurring in:
  1. Vitamin K-dependent protein C light chain
1 copy of Pfam domain PF00008 (EGF-like domain) in Vitamin K-dependent protein C light chain in PDB 1aut.

PF00089
Domain description: Trypsin
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
1 copy of Pfam domain PF00089 (Trypsin) in Vitamin K-dependent protein C heavy chain in PDB 1aut.

CATH InterPro annotations
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Vitamin K-dependent protein C light chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Vitamin K-dependent protein C light chain
IPR013032
Domain description: EGF-like, conserved site
Occurring in:
  1. Vitamin K-dependent protein C light chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
IPR000152
Domain description: EGF-type aspartate/asparagine hydroxylation site
Occurring in:
  1. Vitamin K-dependent protein C light chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Vitamin K-dependent protein C light chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Vitamin K-dependent protein C heavy chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Vitamin K-dependent protein C heavy chain in PDB 1aut.
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Vitamin K-dependent protein C light chain
2 copies of CATH domain 2.10.25.10 (Laminin) in Vitamin K-dependent protein C light chain in PDB 1aut.
SCOP SCOP annotations
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Vitamin K-dependent protein C light chain
2 copies of SCOP domain 57197 (EGF-type module) in Vitamin K-dependent protein C light chain in PDB 1aut.
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Vitamin K-dependent protein C heavy chain
1 copy of SCOP domain 50514 (Eukaryotic proteases) in Vitamin K-dependent protein C heavy chain in PDB 1aut.